Are symptoms of Chronic Deep Vein Thrombosis still impacting the quality of your life?

This study is now closed. For a list of physicians treating chronic DVT with the protocol used in the ACCESS PTS study, click here.


Deep Vein Thrombosis (DVT) occurs when a blood clot or thrombus forms in one of the deep veins in your body, limiting blood flow. It usually occurs in your leg or pelvis. A serious complication of DVT is when a leg blood clot breaks loose and travels in the blood to another area of the body. This is called Venous Thromboembolism. If the clot isn’t dissolved within a few weeks it becomes a Chronic Deep Vein Thrombosis (Chronic DVT). The old blood clot can permanently damage both the vein and the valves that control blood flow in your legs creating a condition called Post-Thrombotic Syndrome (PTS). An estimated 50 percent of patients with Chronic DVT may develop PTS.1,3 PTS can cause long-term disability and impact your quality of life. Some of the symptoms of PTS include:

  • Skin Redness and Discoloration
  • Cramps Itching
  • Tingling or numbness
  • Swelling and Heaviness
  • Chronic Pain
  • Skin Ulcerations

ACCESS PTS -a clinical research study being conducted in the United States for the treatment of Chronic Deep Vein Thrombosis with Post-Thrombotic Syndrome is underway. It includes DVT treatment using the EkoSonic® Endovascular System – an FDA-cleared device that delivers clot-dissolving drugs (thrombolytic drugs) to the thrombus. The purpose of this research study is to evaluate whether your PTS symptoms (blood clot in leg symptoms) improve after the study treatment, how much leg blood clot can be dissolved using the EkoSonic® Endovascular System with a thrombolytic drug (clot-dissolving drug), and how much blood flow can be restored in your leg. There is research data that shows the EkoSonic® System is effective when treating acute blood clots (clots that have recently occurred). With this study, we are conducting research to evaluate how well this system works with clots that are at least 6 months old and have not been responsive to traditional treatments such as elastic compression stockings and blood thinning drugs (anticoagulants).